Victoria Brown-Kennerly, Ph.D., Instructor

Email:

vbrownk(at)genetics.wustl.edu

Education:

2002 Postdoctoral fellow
Department of Genome Sciences
University of Washington
Mentor:  Stanley Fields

2001 Ph.D., Genetics & Molecular Biology
Emory University
Thesis: "RNA-Binding by the Fragile X Mental Retardation Protein"
Mentor: Stephen T. Warren

1993 B.S., Biology
University of Michigan

Awards/Honors:

• 2008  Eukaryotic Cell Outstanding Young Investigator Award (ASM)
• 2006 – 12  NIDDK Mentored Research Scientist Development Award (K01)
• 2002  Damon Runyon Foundation postdoctoral fellowship
• 2002  NIAID National Research Service Award (F32), declined
• 1998  Emory University Excellence in Teaching Award
• 1996 – 97  NIH pre-doctoral training grant

Current Projects:

Sugar sensing through Hgt4 in Candida albicans affects host colonization by this fungus as well as its virulence during blood infections. Current studies are characterizing the specificity and sensitivity of the C. albicans Hgt4 sensor for various sugars, and determining the role Hgt4 plays in gastrointestinal colonization in germ-free mice.

Publications:

1. Sexton, J. A., Brown, V., and M. Johnston (2007) Regulation of sugar transport and metabolism by the Candida albicans Rgt1 transcriptional repressor. Yeast 2007 Oct;24(10):847-60.
2. Brown, V., Sexton, J. A., and M. Johnston (2006) A Glucose Sensor in Candida albicans.  Eukaryotic Cell (5)10: 1726-37.
3. Brown, V., Brown, R. A., Ozinsky, A., Hesselberth, J.R., and S. Fields. (2006) Binding Specificity of the Toll-Like Receptor Cytoplasmic Domains.  European Journal of Immunology 36(3):742-53.
4. Brown, V., Jin, P., Ceman, S., Darnell, J. C., O’Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., Darnell, R. B., and S. T. Warren (2001). Microarray Identification of FMRP-Associated Brain mRNAs and Altered Translational Profile in Fragile X Syndrome. Cell 107(4): 477-487.
5. Darnell, J. C., Jensen, K. B., Jin, P., Brown, V.,Warren, S. T., and R. B. Darnell (2001). Fragile X Mental Retardation Protein mRNA Targets Harboring Intramolecular G-Quartets Encode Proteins Related to Synaptic Function.Cell 107(4): 488-498.
6. Ceman, S., Brown, V., and S. T. Warren (1999).  Isolation of a FMRP-Associated mRNP and the Identification of Nucleolin and the Fragile X - Related Proteins as Components of the Complex. Molecular and Cellular Biology 19(12): 7925-32.
7. Lumeng, C. N., Hauser, M., Brown, V., and J. S. Chamberlain. (1999) Expression of the 71kDa dystrophin isoform (Dp71) evaluated by gene targeting.  Brain Research 830: 174-178.
8. Brown, V., Small, K., Lakkis, L., Feng, Y., Gunter, C., Wilkinson, K. D., and S. T. Warren (1998).  Purified Recombinant Fmrp Exhibits Selective RNA Binding as an Intrinsic Property of the Fragile X Mental Retardation Protein.  The Journal of Biological Chemistry 273:15521-15527.
9. Feng, Y., Absher, D., Eberhart, D. E., Brown, V., Malter, H. E., and S. T. Warren (1997).  FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes this Association.  Molecular Cell. 1:109-118.

Reviews:

1. Vignali, M., and Brown-Kennerly, V. (2002)  Protein-Protein Interactions – A Molecular Cloning Manual (E. Golemis, ed.) The Quarterly Review of Biology (A. D. Carlson and J. D. Thompson, eds.) University of Chicago Press, Chicago, IL.  77(3): 317.
2. Brown,V.,and S. T. Warren (2001).  Trinucleotide Repeats – Dynamic DNA and Human Disease.  The Encyclopedia of Genetics. (S. Brenner and J. H. Miller, eds.), Academic Press, New York, 2001.