Jessica Jackson (Schneider), Senior Research Technician

Email:

jacksonj@genetics.wustl.edu

Education:

2007 M.S. Biology
Saint Louis University

2002 B.A. Biology
University of Missouri – Columbia

Current Project:

Identification and characterization of histone modifications in the yeast S. cerevisiae with our colleague and collaborator Ali Shilatifard (Stowers Institute for Medical Research, Kansas City, Missouri)

Publications:

1. Lee, J.S., Shukla, A., Schneider, J., Swanson, S.K., Washburn M.P., Florens, L., Bhaumik, S.R., Shilatifard, A. (2007) Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell 131(6):1084-96
2. Eissenberg J.C., Lee, M.G., Schneider, J., Ilvarsonn, A., Shiekhattar, R., Shilatifard, A. (2007) The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol. 14(4):344-6
3. Wood, A., Shukla, A., Schneider, J., Lee, J.S., Stanton J.D., Dzuiba, T., Swanson, S.K., Florens, L., Washburn, M.P., Wyrick, J., Bhaumik, S.R., and Shilatifard, A. (2007) Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol. 27(2):709-20
4. Schneider, J., Bajwa, P., Johnson, F.C., Bhaumik, S.R., and Shilatifard, A. (2006) Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem. 281(49):37270-4
5. Tenney, K., Gerber, M., Ilvarsonn, A., Schneider, J., Gause, M., Dorsett, D., Eissenberg, J.C., Shilatifard, A. (2006) Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci USA 103(32):11970-4
6. Wood, A., Schneider, J., Dover, J., Johnston, M., Shilatifard, A. (2005) The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell 20(4):589-99
7. Schneider, J., Wood, A., Lee, J.S., Schuster, R., Dueker, J., Maguire, C., Swanson, S.K., Florens, L., Washburn, M.P., Shilatifard, A. (2005) Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell 19(6):849-56
8. Schneider, J., Dover, J., Johnston, M., Shilatifard, A. (2004) Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications. Methods Enzymol. 377:227-34
9. Wood, A., Schneider, J., Dover, J., Johnston, M., and Shilatifard, A. (2003) The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem. 278(37):34739-42
10. Krogan, N.J., Dover, J., Wood, A., Schneider, J., Heidt, J., Boateng, M.A., Dean, K., Ryan, O.W., Golshani, A., Johnston, M., Greenblatt, J.F., and Shilatifard, A. (2003) The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p:linking transcriptional elongation to histone methylation. Mol Cell 11(3):721-9
11. Wood, A., Krogan, N.J., Dover, J., Schneider, J., Heidt, J., Boateng, M.A., Dean, K., Golshani, A., Zhang, Y., Greenblatt, J.F., Johnston, M., and Shilatifard, A. (2003) Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell 11(1):267-74
12. Dover, J., Schneider, J., Tawiah-Baoteng, M.A., Wood, A., Dean, K., Johnston, M., and Shilatifard, A. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem, 277(32):28368-71
13. Krogan, N.J., Dover, J., Khorrami, S., Greenblatt, J.F., Schneider, J., Johnston, M., and Shilatifard, A. (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem. 277(13):10753-5

Reviews:

1. Schneider, J. and Shilatifard, A. (2006) Histone demethylation by hydroxylation: chemistry in action. ACS Chem Biol. 1(2):75-81
2. Wood, A., Schneider, J., Shilatifard, A. (2005) Cross-talking histones: implications for the regulation of gene expression and DNA repair. Biochem Cell Biol. 83(4):460-7