Makedonka Mitreva, Ph.D.
Assistant Director, The Genome Center
Research Assistant Professor of Genetics

mmitreva@watson.wustl.edu

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Publications

2009:

Zhengyuan Wang, John Martin, Sahar Abubucker, Yong Yin, Robin B. Gasser, Makedonka Mitreva. Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance, 2009, BMC Evolutionary Biology,Publication Link
John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang and Makedonka Mitreva. Nematode.net update 2008: improvements enabling more efficient data mining and comparative nematode genomics, 2009 Nucleic Acids Research, 37(Database issue):D571-8.Publication Link

2008:

Integrating genomics and phylogenetics in understanding the history of Trichinella species. Zarlenga DS, Rosenthal B, Hoberg E, Mitreva M. 2008., 2008, Veterinary Parasitology, Oct 22. [Epub ahead of print], PMID: 19046815.Publication Link
NemaPath: online exploration of KEGG-based metabolic pathways for nematodes. Todd Wylie, John Martin, Sahar Abubucker, Yong Yin, David Messina, Zhengyuan Wang, James P. McCarter and Makedonka Mitreva , 2008, BMC Genomics, 9(1):525.Publication Link
Role of lateral gene transfer in the evolution of plant parasitism among nematodes. Makedonka Mitreva, Geert Smant and Hans Helder, In HGT - Genomes in flux,, 2008, in-press (invited book chapter).
Large-scale sequencing and analytical processing of ESTs. Makedonka Mitreva and Elaine R. Mardis. In Methods in Molecular Biology, 2008, in-press (invited book chapter).
Expressed Sequence Tags: Generation and Analysis Methods. Sandra W. Clifton and Makedonka Mitreva. Strategies for undertaking Expressed Sequence Tags projects. In Methods in Molecular Biology, 2008, in press. (invited book chapter).
The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism. Dieterich C, Clifton SW, Schuster LN, Chinwalla A, Delehaunty K, Dinkelacker I, Fulton L, Fulton R, Godfrey J, Minx P, Mitreva M, Roeseler W, Tian H, Witte H, Yang SP, Wilson RK, Sommer RJ. Nat Genet. 2008 Oct;40(10):1193-8. Epub 2008 Sep 21. PMID: 18806794.Publication Link
Mining the secretome of the root-knot nematode Meloidogyne chitwoodi for candidate parasitism genes. Erwin Roze, Hanse B, Makedonka Mitreva, Bartel Vanholme, Jaap Bakker and Geert Smant. Molecular Plant Pathology, 2008; 9(1): 1-10. Publication Link
Intestinal Transcriptomes of Nematodes: Comparison of the Parasites Ascaris suum and Haemonchus contortus with the Free-living Caenorhabditis elegans. Yong Yin, John Martin, Sahar Abubucker, Alan L. Scott, James P. McCarter, Richard K. Wilson, Douglas P. Jasmer, and Makedonka Mitreva, PLoS Neglected Tropical Diseases 2008, 2: e269.Publication Link
Advances on sequencing the genome of the Clade I nematode Trichinella spiralis. Makedonka Mitreva and Douglas P. Jasmer, Parasitology, 2008, 135: 869-80 (Review).
Genome analysis of the platypus reveals unique signatures of evolution Wesley C. Warre...Makedonka Mitreva ...and Richard K. Wilson, , Nature, 2008, 453(7192):175-183Publication Link
Exploring the transcriptome of the burrowing nematode Radopholus similis, Molecular Genetics and Genomics, Joachim Jacob, Makedonka Mitreva, Bartel Vanholme, Godelieve Gheysen, Exploring the transcriptome of the burrowing nematode Radopholus similis, Molecular Genetics and Genomics, 2008, 280:1-17.Publication Link
The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences, Sahar Abubucker, John Martin, Yong Yin, Lucinda Fulton, Shiaw-Pyng Yang, Kym Hallsworth-Pepin, J. Spencer Johnston, John Hawdon, James P. McCarter, Richard K. Wilson and Makedonka Mitreva. Molecular and Biochemical Parasitology, 2007.Publication Link

2007:

The bandit, a New DNA Transposon from a Hookworm - Possible Horizontal Genetic Transfer between Host and Parasite Laha T, Loukas A, Wattanasatitarpa S, Somprakhon J, Kewgrai N, Sithithaworn P, Kaewkes S, Makedonka Mitreva and Paul J. Brindley, PLOS Neglected Tropical Diseases; 2007, 1(1): e35. doi:10.1371/journal.pntd.0000035. Publication Link
Divergent evolution of arrested development in the dauer stage of Caenorhabditis elegans and the infective stage of heterodera glycines. Axel A. Elling, Makedonka Mitreva, Justin Recknor, Xiaowu Gai, John Martin, Thomas R. Maier, Jeffrey P. McDermott, Tarek Hewezi, David McK. Bird, Eric L. Davis, Richard S. Hussey, Dan Nettleton, James P. McCarter, and Thomas J. Baum, Genome Biol. 2007; 8(10): R211. Publication Link
Genome Sequence of the Parasitic Nematode Brugia Malayi, Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen J, Mitreva M, Scott A et al., The Biology of Parasitism, Science 2007, 317(5845):1756-60, Publication Link
Mining the secretome of the root nematode Meloidogyne chitwoodi for candidate paracitism genes, Roze E, Hanse B, Mitreva M, Vanholme B, Bakker J and Smant G , Molecular Plant Pathology 2007. Publication Link
The bandit transposon, a mariner-like mobile genetic element from the genome of the hookworm, Ancylostoma caninum: inferred horizontal transmission between host and parasite, Laha T, Loukas A, Wattanasatitarpa S, Somprakhon J, Kewgrai N, Loukas A, Sithithaworn P, Kaewkes S, Mitreva M, Brindley PJ. PLoS Neglected Tropical Diseases 2007. Publication Link

2006:

Biology and genome of Trichinella spiralis, M. Mitreva, Douglas P. Jasmer, Wormbook 2006 Publication Link
Codon usage patterns in Nematoda: analysis based on over 25 million codons in thirty-two species, Mitreva M, Wendl MC, Martin J, Wylie T, Yin Y, Larson A, Parkinson J, Waterston RH, McCarter JP, Genome Biol. 2006 Aug 14;7(8):R75 Publication Link
A symbiont-independent endo-1,4-beta-xylanase from the plant-parasitic nematode Meloidogyne incognita, Mitreva-Dautova M, Roze E, Overmars H, de Graaff L, Schots A, Helder J, Goverse A, Bakker J, Smant G. , Mol Plant Microbe Interact. 2006 , May;19(5):521-9 Publication Link
Identification and Analysis of Genes Expressed in the Adult Filiarial Nematode Dirofilaria immitis, Yin, Y., J. Martin, J. P. McCarter, S. W. Clifton, R. K. Wilson, and M. Mitreva, International Journal of Parasitology 2006, 36(7):829-39 Publication Link
Brugia malayi: effects of radiation and culture on gene expression in infective larvae, Li BW, Rush AC, Weil GJ, McCarter JP, Mitreva M, Mol Biochem Parasitol. 2006 Oct;149(2):201-7 Publication Link
Detection of Proteins Secreted by the Plant-parasitic Nematode Heterodera schachtii, Vanholme, B., M. Mitreva, W. V. Criekinge, M. Logghe, J. P. McCarter, and G. Gheysen, Parasitology Research 2006, 98(5):414-24 Publication Link

2005:

Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis, Ben-Wen Li, AC Rush, SD Crosby, W Warren, SA Williams, M. Mitreva, GJ Weil, Molecular and Biochemical Parasitology 2005, 143: 49-57 Publication Link
A White Paper on Nematode Comparative Genomics, Bird, D. M., M. L. Blaxter, J. P. McCarter, M. Mitreva, P. W. Sternberg, W. K. Thomas, Journal of Nematology 2005, 37(4):408-416PDF file
Nematode Gene Sequences: Update for December, 2005, McCarter, J. P., D. M. Bird, M. Mitreva, Journal of Nematology 2005, 37(4):417-421 Publication Link
Comparative genomics of nematodes, Mitreva M,Blaxter ML,Bird DM,McCarter JP, Trends Genet 2005, Oct.21(10):573-81 Publication Link
Expressed Sequence Tags From Life Cycle Stages of Trichinella spiralis: Application to Biology and Parasite Control, Mitreva, M., J. Appleton, J. P. McCarter, and D. P. Jasmer, Veterinary Parasitology 2005, 132:13-17 Publication Link
Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis, Li B, Rush AC, Crosby SD, Warren W, Williams SA, Mitreva M, Weil GJ, Molecular and Biochemical Parasitology 2005, 143: 49-57Publication Link
An Expressed Sequence Tag Analysis of the Life-cycle of the Parasitic Nematode Strongyloides ratti, Thompson, F. J., M. D. Mitreva, G. L. A. Barker, J. Martin, R. H. Waterston, J. P. McCarter, and M. E. Viney, Molecular and Biochemical Parasitology 2005, 142:32-46 Publication Link
Investigating Hookworm Genomes by Comparative Analysis of Two Ancylostoma Species, Mitreva, M., J. P. McCarter, P. Arasu, J. Hawdon, J. Martin, M. Dante, T. Wylie, J. Xu, J. E. Stajich, V. Kapulkin, S. W. Clifton, R. H. Waterston, and R. Wilson, BMC Genomics 2005, 6:58,1-19 Publication Link

2004

A transcriptomic analysis of the phylum Nematoda, Parkinson J, Mitreva M, Whitton C, Thomson M, Daub J, Martin J, Schmid R, Hall N, Barrell B, Waterston RH, McCarter JP, Blaxter ML, Nat Genet. 2004 Nov 14Publication Link
mRNA Sequences for Haemonchus contortus intestinal cathepsin B-like cysteine proteases display an extreme in abundance and diversity among mammalian parasitic nematodes, Jasmer, D. P., M. D. Mitreva, J. P. McCarter, Molecular and Biochemical Parasitology 2004, 137:297-305. PDF File
Gene discovery in the adenophorean nematode Trichinella spiralis: an analysis of transcription from three life cycle stages , Mitreva, M., D. P. Jasmer, J. Appleton, J. Martin, M. Dante, T. Wylie, S. W. Clifton, and R. H. Waterston, and J. P., McCarter, Molecular and Biochemical Parasitology 2004, 137:277-291 PDF File
A survey of SL1-spliced transcripts from the root-lesion nematode Pratylenchus penetrans, Mitreva M, Elling AA, Dante M, Kloek AP, Kalyanaraman A, Aluru S, Clifton SW, Bird DM, Baum TJ, McCarter JP, Molecular Genetics and Genomics 2004, 272:2, 138-148 Publication Link
Comparative Genomics of Gene Expression in the Parasitic and Free-living Nematodes Strongyloides stercoralis and Caenorhabditis elegans, Mitreva, M. D., J. P., McCarter, J. Martin, M. Dante, T. Wylie, B. Chiapelli, D. Pape, S. W. Clifton, T. B. Nutman, and R. H. Waterston, Genome Research 2004, Feb.14(2):209-20 Publication Link
Nematode.net: A Tool for Navigating Sequences from Parasitic and Free-living Nematodes, Wylie, T., Martin J.C., Dante M., Mitreva M.D., Clifton S.W., Chinwalla A., Waterston R.H., Wilson R.K., and McCarter J.P, Nucleic Acids Research 2004, 32:D423-D426 PDF File

2003 and earlier:

400,000 Nematode ESTs on the Net, Parkinson, J., M. Mitreva, N. Hall, M. Blaxter, and J. P. McCarter. 400,000 Nematode ESTs on the Net. Trends in Parasitology 2003, 19:283-286 PDF File
Analysis and Functional Classification of Transcripts from the Nematode Meloidogyne incognita, McCarter, J. P., M. D. Mitreva, J. Martin, M. Dante, T. Wylie, U. Rao, D. Pape, Y. Bowers, B. Theising, C. Murphy, A. P. Kloek, B. Chiapelli, S. W. Clifton, D. McK. Bird, and R. H. Waterston, Genome Biology 2003, 4:R26,1-19 PDF File
Nematode Gene Sequences, Update for December, McCarter, J. P., M. Mitreva, S. W. Clifton, D. McK. Bird and R. H. Waterston, Journal of Nematology, 2003 PDF File
Nematode Gene Sequences, Update for December 2000, McCarter, J. P., D. McK. Bird, S. W. Clifton, and R. H. Waterston, Journal of Nematology 2000, 32(4):331-333PDF File

 

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