Courses

Title:
Computational Molecular Biology

Instructor:
Eddy

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
3 Units

Frequency / Last Offered:
Annually / FL2004 History

Attributes:
None

Description:
A detailed survey of the mathematical and algorithmic basis for methods in computational molecular biology. Topics covered include sequence alignment algorithms, multiple sequence alignment, RNA structure prediction, motif and pattern searches, and phylogenetic inference. Two lectures per week, plus a discussion section each week in which students present a current paper in the field. Students will acquire a working knowledge of UNIX and the C programming language during the course. There are no formal prerequisites, but prior experience in computer programming and an aptitude for mathematics are almost essential. The course is generally too advanced for biologists simply seeking to learn how to use common bioinformatics tools.
_______________________________________________________________________
Course:
L41 Biol 5488

Title:
Genomics

Instructor:
Cohen

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
Variable

Frequency / Last Offered:
Annually / SP2005 History

Attributes:
None

Description:
A hybrid of concepts and practical applications in genomics. Areas covered include how genomes are mapped and sequenced, computational methods for gene predictions, functional genomic techniques for ascribing function to DNA, RNA and protein sequence and how genomic techniques and resources can advance the study of human disease. Heavy emphasis will be placed on students acquiring basic skills needed to navigate and manipulate databases of DNA sequence, gene expression and other types of genome wide data. Prerequisites, Molecular Cell Biology (Bio 5068), Nucleic Acids (Bio 548) or by permission of instructor. Lecture 3 units of credit; lab 1 additional unit, space limited.

_______________________________________________________________________
Course:
L41 Biol 5491

Title:
Advanced Genetics

Instructor:
Schedl
http://www.genetics.wustl.edu/bio5491/index.htm

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
3 Units

Frequency / Last Offered:
Annually / SP2005 History

Attributes:

A&S : NS

Description:
Fundamental aspects of organismal genetics with emphasis on experimental studies that have contributed to the molecular analysis of complex biological problems. Examples drawn from bacteria, yeast, nematodes, fruit flies and mammalian systems. Prerequisite, graduate standing or permission of instructor.
_______________________________________________________________________
Course:
L41 Biol 5493

Title:
Subversive Genetics, Attacks on the Central Dogma

Instructor:
Johnson

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
2 Units

Frequency / Last Offered:
Annually / FL2004 History

Attributes:
None

Description:
Exceptions to the central dogma of genetics and molecular biology are identified and examined. Particular care is paid to identifying strategies to resolve mechanistic bases of these phenomena. Prerequisites, Advanced Genetics.
_______________________________________________________________________
Course:
L41 Biol 5496

Title:
Seminar in Computational Molecular Biology
Instructor:
Stormo

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
1 Unit

Frequency / Last Offered:
< None> / FL2004 History

Attributes:
None

Description:
This is a journal club and discussion group in which recent papers and new methods in computational biology are presented each week for discussion. Emphasis is on critical examination of the approaches, results and conclusions.
_______________________________________________________________________
Course:
L41 Biol 5235

Title:
Genetics Journal Club
Instructor:
Dutcher

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
1 Unit

Frequency / Last Offered:
Every Semester / SP2005 History

Attributes:

A&S : NS

Description:
This journal club will be focused on the Genetics department seminar series. Students will present one or a few recent papers by the seminar speaker scheduled for that week. Students will provide a brief written evaluation (on a form that will be provided) of their peers´ presentations, and the faculty advisors will meet with each student after the presentation to provide feedback.
_______________________________________________________________________
Course:
L41 Biol 5484

Title:
Genetics and Development of C. elegans Journal Club

Instructor:
Schedl

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
1 Unit

Frequency / Last Offered:
Every Semester / SP2005 History

Attributes:

A&S : NS

Description:
Students will present a research paper (or present their current thesis research) and the appropriate background material.
_______________________________________________________________________
Course:

Title:
Human Linkage and Association Analysis

Instructor:
Bowcock

School:
Arts and Sciences

Department:
BIOLOGY AND BIOMEDICAL SCIENCES (L41)

Credit:
1 Unit

Frequency / Last Offered:
Every Semester / SP2005 History

Attributes:

A&S : NS

Description:
Identification of human genes is becoming easier and faster. Approaches rely on families with disease, marker typing and homing in on disease genes with DNA resequencing and association studies. This course will provide you with the tools to identify genes for both simple Mendelian traits and complex traits. Both linkage analyses and association analyses are explained, and hands-on computer training in these types of analyses is also employed.