Advanced Genetics Spring 2008 Bio5491
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Advanced Genetics Spring 2008 Bio5491
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OVERVIEW Bio5491 - Advanced Genetics provides an overview of basic concepts and techniques in genetics and their use in answering fundamental questions in biology. The lectures focus primarily on studies carried out in yeast, C. elegans, Drosophila, mouse, and humans to illustrate the power of genetics as an experimental tool. |
Format of the Course We have two lectures per week plus a discussion group or a Special Topics lecture on Monday. Class meets Tues/Thurs 2:00-3:30 in 823 McDonnell Sciences Building. First day of class is Tuesday January 15 and last day of class is April 15. On Mondays we either have a discussion group similar to those for MCB and Nucleic Acids or a Special Topics Lecture. Special Topics lectures are from 12-1 in 823 McDonnell; the time and place for the individual discussion groups vary and will be determined the first week of class. The major project for the course is to write an NIH style post-doctoral fellowship proposal. Abstracts and Specific Aims of the proposal are due February 29. The proposal is due by NOON on Friday, April 25th. Study Sections will be held the week of May 5-9 from 1:00-5:00 pm. Each student is required to attend one study section. Each student will be given two proposal for a particular Study Section and that student is required to read and to provide a written and oral critique of both proposals at the Study Section. |
Schedule *If you are having difficulty accessing any links below, please contact Cailin...THANKS!* |
| Date | Topic | Lecturer | Papers/Notes |
| Jan 15 | Introduction; Yeast Genetics | Mark Johnston | |
| Jan 17 | Yeast Genetics | Mark Johnston | |
| Jan 21 | Discussion section - Basic genetics review | Cailin Joyce | |
| Jan 22 | Arabidopsis Genetics | Elizabeth Haswell | |
| Jan 24 | Yeast Genetics | Mark Johnston | Johnston slides II |
| Jan 28 | Discussion Section - Research proposals | Jim Skeath | Grant guidelines |
| Jan 29 | C. elegans Genetics | Kerry Kornfeld | |
| Jan 31 | C. elegans Genetics | Tim Schedl | |
| Feb 4 | Discussion Section- Research proposals | Small groups | |
| Feb 5 | C. elegans Genetics **JOHNSTON PROBLEM SET DUE** |
Tim Schedl | |
| Feb 7 | C. elegans Genetics | Tim Schedl | |
| Feb 11 | Discussion Section - Mapping | Cailin Joyce | |
| Feb 12 | C. elegans Genetics | Kerry Kornfeld | |
| Feb 14 | Systematic Genetics | Tim Schedl | |
| Feb 18 | Discussion Section- Paper | Small groups | Ambros 1989 |
| Feb 19 | Drosophila Genetics **KORNFELD PROBLEM SET DUE** |
Jim Skeath | |
| Feb 22 | Drosophila Genetics | Jim Skeath | Genomic disorders |
| Feb 25 | Discussion Section- Paper | Small groups | Lum et al. 2004 |
| Feb 26 | Drosophila Genetics | Jim Skeath | Zhai et al. 2003 |
| Feb 28 | Drosophila Genetics | Jim Skeath | Genetic screens |
| Feb 29 | GRANT ABSTRACTS and SPECIFIC AIMS DUE FRIDAY AT NOON in Genetics Office |
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| Mar 3 | Drosophila Genetics | Jim Skeath | |
| Mar 4 | Drosophila Genetics **SCHEDL PROBLEM SET DUE** |
Jim Skeath | "Discs lost..." |
| Mar 6 | Zebrafish Genetics | Matt Goldsmith | |
| Spring Break - March 8-16 - Enjoy! | |||
| Mar 17 | Discussion Section- Paper | Small groups | Simon et al. 1991 |
| Mar 18 | Mouse genetics **SKEATH PROBLEM SET DUE** |
Dave Ornitz | Ornitz lab website and slides |
| Mar 20 | Mouse genetics | Dave Ornitz | |
| Mar 24 | Discussion Section- Paper | Small groups | Pielage et al. 2003 |
| Mar 25 | Quantitative Genetics | Justin Fay | |
| Mar 27 | Quantitative Genetics | Justin Fay | Fay problem set |
| Mar 31 | Discussion Section- Paper | Small groups | Long et al. 2000 |
| Apr 1 | Human Genetics **ORNITZ PROBLEM SET DUE** |
Anne Bowcock | Bowcock slides |
| Apr 3 | Human Genetics | Alison Goate | Goate slides |
| Apr 7 | Discussion Section- miRNAs | Cailin Joyce | miRNA slides |
| Apr 8 | Human Genetics | Nancy Saccone | |
| Apr 10 | Human Genetics | Mike Lovett | Lovett slides |
| Apr 14 | Discussion section | - | |
| Apr 15 | Human Genetics **FAY PROBLEM SET DUE** |
Watson | Watson slides |
| Apr 25 | Grants Due in Genetics Office by NOON |
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| April 28 | Grants returned for Review - Noon - 823 McDonnell |
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| May 5-9 | Study Sections - 1-5pm; 823 McDonnell Sciences | - | |