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OVERVIEW
Bio5491 – Advanced Genetics provides an overview of basic concepts and techniques in genetics and their use in answering fundamental questions in biology. The lectures focus primarily on studies carried out in yeast, C. elegans, Drosophila, mouse, and humans to illustrate the power of genetics as an experimental tool.
FORMAT OF THE COURSE
We have two lectures per week plus a discussion group or a Special Topics lecture on Monday. Class meets Tues/Thurs 2:00-3:30 in 823 McDonnell Sciences Building. First day of class is Tuesday January 19 and last day of class is April 13. On Mondays we either have a discussion group similar to those for MCB and Nucleic Acids or a Special Topics Lecture. Special Topics lectures are from 12-1 in 823 McDonnell; the time and place for the individual discussion groups vary and will be determined the first week of class.
The major project for the course is to write an NIH style post-doctoral fellowship proposal. Abstracts and Specific Aims of the proposal are due March 1. The proposal is due by NOON on Friday, April 30th. Study Sections will be held on May 10, 11 & 12 from 1:00-5:00 pm. Each student is required to attend one study section. Each student will be given two proposal for a particular Study Section and that student is required to read and to provide a written and oral critique of both proposals at the Study Section.
SCHEDULE
*If you have difficulty accessing any links below, please contact Sarah Jinn at sarahj38@gmail.com.
*Please refer to updated schedules for problem set due dates.
Date
Topic
Lecturer
Papers/Notes
Jan 19
Introduction; C. elegans Genetics
Tim Schedl/ Kerry Kornfeld
Course Intro&Expectations
Jan 21
C. elegans Genetics
Tim Schedl
C. elegans genetic methods
Jan 25
Discussion section – Genetic Principles
Sarah Jinn
Organism Databases
Jan 26
C. elegans Genetics
Tim Schedl
Art and Design_Celegans
Jan 28
C. elegans Genetics
Tim Schedl
Feb 1
Discussion Section – Research proposals I
Tim Schedl
AdvGenRes.Proposal.2010
Feb 2
C. elegans Genetics
Kerry Kornfeld
Feb 4
Zebrafish Genetics
Solnica-Krezel
Zebrafish lecture slides_smaller file
Feb 8
Discussion Section- Research proposals II
Small groups
Example 1_LongChainFA
Feb 9
Yeast Genetics
Susan Dutcher
Kornfeld Problem Set due
Feb 11
Yeast Genetics
Susan Dutcher
Feb 15
Discussion Section
Small groups
AmbrosV.1989
Feb 16
Yeast Genetics
Susan Dutcher
Feb 18
High Throughput Genetics
Tim Schedl
Feb 22
Discussion Section- Mapping
Sarah Jinn
Feb 23
Mouse genetics
Dave Ornitz
Schedl Problem set due
Feb 25
Mouse genetics
Dave Ornitz
Mar 1
Proposal abstract and specific aims are due. Email PDF of your document to advancedgenetics@genetics.wustl.edu by MIDNIGHT
Mar 1
Discussion Section- Paper
Small groups
Mar 2
Quantitative Genetics
Justin Fay
Mar 4
Quantitative Genetics
Justin Fay
March 7-14 Spring Break
Mar 15
Discussion Section- Paper
Small groups
Mar 16
Drosophila Genetics
Jim Skeath
Mar 18
Drosophila Genetics
Jim Skeath
Mar 22
Discussion Section- Paper
Small groups
Mar 23
Drosophila Genetics
Jim Skeath
Mar 25
Drosophila Genetics
Jim Skeath
Mar 29
Discussion Section- Paper
Small groups
Mar 30
Human Genetics
Mike Lovett/Anne Bowcock
Apr 1
Cancer Genetics
Paul Goodfellow
Apr 5
Discussion Section- Paper
Small Groups
Apr 6
Human Genetics
Mike Lovett/Anne Bowcock
Apr 8
Human Genetics
Mike Lovett/Anne Bowcock
Apr 12
Discussion Section – Topics in Human Genetics
Sarah Jinn
Apr 13
Human Genetics
Mike Lovett/Anne Bowcock
Apr 30
Proposal due by Noon
May 3
Grants returned for Review – Noon – 823 McDonnell
May 10-12
Study Sections – 1-5pm; 823 McDonnell Sciences (must attend one day)
| OVERVIEW
Bio5491 – Advanced Genetics provides an overview of basic concepts and techniques in genetics and their use in answering fundamental questions in biology. The lectures focus primarily on studies carried out in yeast, C. elegans, Drosophila, mouse, and humans to illustrate the power of genetics as an experimental tool. |
| FORMAT OF THE COURSE We have two lectures per week plus a discussion group or a Special Topics lecture on Monday. Class meets Tues/Thurs 2:00-3:30 in 823 McDonnell Sciences Building. First day of class is Tuesday January 19 and last day of class is April 13. On Mondays we either have a discussion group similar to those for MCB and Nucleic Acids or a Special Topics Lecture. Special Topics lectures are from 12-1 in 823 McDonnell; the time and place for the individual discussion groups vary and will be determined the first week of class. The major project for the course is to write an NIH style post-doctoral fellowship proposal. Abstracts and Specific Aims of the proposal are due March 1. The proposal is due by NOON on Friday, April 30th. Study Sections will be held on May 10, 11 & 12 from 1:00-5:00 pm. Each student is required to attend one study section. Each student will be given two proposal for a particular Study Section and that student is required to read and to provide a written and oral critique of both proposals at the Study Section. |
|
SCHEDULE *If you have difficulty accessing any links below, please contact Sarah Jinn at sarahj38@gmail.com. *Please refer to updated schedules for problem set due dates. |
| Date | Topic | Lecturer | Papers/Notes |
| Jan 19 | Introduction; C. elegans Genetics | Tim Schedl/ Kerry Kornfeld | Course Intro&Expectations |
| Jan 21 | C. elegans Genetics | Tim Schedl | C. elegans genetic methods |
| Jan 25 |
Discussion section – Genetic Principles | Sarah Jinn |
Organism Databases |
| Jan 26 | C. elegans Genetics | Tim Schedl | Art and Design_Celegans |
| Jan 28 | C. elegans Genetics | Tim Schedl | |
| Feb 1 | Discussion Section – Research proposals I | Tim Schedl | AdvGenRes.Proposal.2010 |
| Feb 2 | C. elegans Genetics | Kerry Kornfeld | |
| Feb 4 | Zebrafish Genetics | Solnica-Krezel | Zebrafish lecture slides_smaller file |
| Feb 8 | Discussion Section- Research proposals II | Small groups | Example 1_LongChainFA |
| Feb 9 | Yeast Genetics | Susan Dutcher | Kornfeld Problem Set due |
| Feb 11 | Yeast Genetics | Susan Dutcher | |
| Feb 15 | Discussion Section | Small groups | AmbrosV.1989 |
| Feb 16 | Yeast Genetics | Susan Dutcher | |
| Feb 18 | High Throughput Genetics | Tim Schedl | |
| Feb 22 |
Discussion Section- Mapping | Sarah Jinn | |
| Feb 23 | Mouse genetics | Dave Ornitz | Schedl Problem set due |
| Feb 25 | Mouse genetics | Dave Ornitz | |
| Mar 1 |
Proposal abstract and specific aims are due. Email PDF of your document to advancedgenetics@genetics.wustl.edu by MIDNIGHT
|
||
| Mar 1 | Discussion Section- Paper | Small groups | |
| Mar 2 | Quantitative Genetics | Justin Fay | |
| Mar 4 | Quantitative Genetics | Justin Fay | |
| March 7-14 Spring Break |
|||
| Mar 15 |
Discussion Section- Paper | Small groups | |
| Mar 16 | Drosophila Genetics | Jim Skeath | |
| Mar 18 | Drosophila Genetics | Jim Skeath | |
| Mar 22 | Discussion Section- Paper | Small groups | |
| Mar 23 | Drosophila Genetics | Jim Skeath | |
| Mar 25 | Drosophila Genetics | Jim Skeath | |
| Mar 29 | Discussion Section- Paper | Small groups | |
| Mar 30 | Human Genetics | Mike Lovett/Anne Bowcock | |
| Apr 1 | Cancer Genetics | Paul Goodfellow | |
| Apr 5 |
Discussion Section- Paper | Small Groups | |
| Apr 6 | Human Genetics | Mike Lovett/Anne Bowcock | |
| Apr 8 | Human Genetics | Mike Lovett/Anne Bowcock | |
| Apr 12 | Discussion Section – Topics in Human Genetics |
Sarah Jinn |
|
| Apr 13 | Human Genetics | Mike Lovett/Anne Bowcock | |
| Apr 30 |
Proposal due by Noon
|
||
| May 3 | Grants returned for Review – Noon – 823 McDonnell | ||
| May 10-12 | Study Sections – 1-5pm; 823 McDonnell Sciences (must attend one day) | ||