Spring 2012
OVERVIEW
Bio5491 – Advanced Genetics provides an overview of basic concepts and techniques in genetics and their use in answering fundamental questions in biology. The lectures focus primarily on studies carried out in yeast, C. elegans, Drosophila, mouse, and humans to illustrate the power of genetics as an experimental tool.
FORMAT OF THE COURSE
We have two lectures per week plus a discussion group or a Special Topics lecture on Monday.
Class meets Tuesday/Thursday 2:00-3:30 in 823 McDonnell Sciences Building. First day of class is January 17 and last day of class is April 10.
On Mondays we either have a discussion group similar to those for MCB and Nucleic Acids or a Special Topics Lecture. Special Topics lectures are from 12:00-1:00 in 823 McDonnell; the time and place for the individual discussion groups vary and will be determined the first week of class.
Thursdays after class at 3:30, there will be review sessions on homework or course material.
The major project for the course is to write an NIH style post-doctoral fellowship proposal. Abstracts and Specific Aims of the proposal are due March 19. The proposal is due by NOON on Friday, April 27. Study Sections will be held on May 7, 8 & 9 from 1:00-5:00 pm. Each student is required to attend one study section. Each student will be given two proposal for a particular Study Section and that student is required to read and to provide a written and oral critique of both proposals at the Study Section.
SCHEDULE
*If you have difficulty accessing any links below, please contact Kurt Warnhoff at kjw879@gmail.com.
*Please refer to updated schedules for problem set due dates.
Date
Topic
Lecturer
Papers/Notes
Jan 17
Introduction
C. elegans genetics
Tim Schedl / Kerry Kornfeld
Warnhoff_ProblemSet
Jan 19
C. elegans genetics
Tim Schedl
C. elegans genetic methods
Jan 23
Discussion section – Genetic Principles
Kurt Warnhoff
Warnhoff problem set due
Jan 24
C. elegans genetics
Tim Schedl
Art and Design_Celegans
Jan 26
C. elegans genetics
Tim Schedl
Jan 30
Discussion Section – Research proposals I
Tim Schedl
Research Proposal Guidelines 2012
Jan 31
C. elegans genetics
Kerry Kornfeld
Feb 2
Zebrafish genetics
Kelly Monk
Monk_ZF Genetics 2012_Part1
Feb 6
Discussion Section- Research proposals II
small groups
Example proposal 1_LongChainFA
Feb 7
Yeast genetics
Susan Dutcher
Feb 9
Yeast genetics
Susan Dutcher
Feb 13
Discussion Section
small groups
AmbrosV_1989
Feb 14
Yeast Genetics
Susan Dutcher
Feb 16
High throughput genetics
Tim Schedl
Feb 20
Discussion Section
small groups
Lum_et_al.Cell 2004
Feb 21
Drosophila genetics
Jim Skeath
Kornfeld Problem Set Due
Feb 23
Drosophila genetics
Jim Skeath
Feb 27
Arabidopsis genetics
Feb 28
Drosophila genetics
Jim Skeath
Mar 1
Drosophila genetics
Jim Skeath
Mar 5
Discussion Section – Paper
Small groups
Mar 6
Mouse genetics
Dave Ornitz
SPRING BREAK – MARCH 10- 18
Mar 19
Abstract and Specific Aims Due for Proposal
Mar 20
Quantitative genetics
Justin Fay
Mar 22
Quantitative genetics
Justin Fay
Mar 26
Discussion Section-paper TBA
Small groups
Mar 27
Human genetics
Bowcock/Lovett
Mar 29
Human genetics
Bowcock/Lovett
Apr 2
Discussion Section-paper TBA
Small Groups
Apr 3
Human genetics
Bowcock/Lovett
Apr 5
Human genetics
Goodfellow
Apr 9
Discussion Section
Small groups
Apr 10
Human genetics
Bowcock/Lovett
Apr 27
Research Proposals due Friday April 27 at 12:00pm (NOON) Email the Proposal to: advancedgenetics@genetics.wustl.edu
April 30
Grants returned for Review – Noon – 823 McDonnell
May 7,8, and 9
Study Sections – 1-5pm; 823 McDonnell Sciences (must attend one day)
| OVERVIEW
Bio5491 – Advanced Genetics provides an overview of basic concepts and techniques in genetics and their use in answering fundamental questions in biology. The lectures focus primarily on studies carried out in yeast, C. elegans, Drosophila, mouse, and humans to illustrate the power of genetics as an experimental tool. |
| FORMAT OF THE COURSE We have two lectures per week plus a discussion group or a Special Topics lecture on Monday. Class meets Tuesday/Thursday 2:00-3:30 in 823 McDonnell Sciences Building. First day of class is January 17 and last day of class is April 10. On Mondays we either have a discussion group similar to those for MCB and Nucleic Acids or a Special Topics Lecture. Special Topics lectures are from 12:00-1:00 in 823 McDonnell; the time and place for the individual discussion groups vary and will be determined the first week of class. Thursdays after class at 3:30, there will be review sessions on homework or course material. The major project for the course is to write an NIH style post-doctoral fellowship proposal. Abstracts and Specific Aims of the proposal are due March 19. The proposal is due by NOON on Friday, April 27. Study Sections will be held on May 7, 8 & 9 from 1:00-5:00 pm. Each student is required to attend one study section. Each student will be given two proposal for a particular Study Section and that student is required to read and to provide a written and oral critique of both proposals at the Study Section. |
|
SCHEDULE *If you have difficulty accessing any links below, please contact Kurt Warnhoff at kjw879@gmail.com. *Please refer to updated schedules for problem set due dates. |
| Date | Topic | Lecturer | Papers/Notes |
| Jan 17 | Introduction C. elegans genetics |
Tim Schedl / Kerry Kornfeld | Warnhoff_ProblemSet |
| Jan 19 | C. elegans genetics | Tim Schedl | C. elegans genetic methods |
| Jan 23 |
Discussion section – Genetic Principles | Kurt Warnhoff |
Warnhoff problem set due |
| Jan 24 | C. elegans genetics | Tim Schedl | Art and Design_Celegans |
| Jan 26 | C. elegans genetics | Tim Schedl | |
| Jan 30 | Discussion Section – Research proposals I | Tim Schedl | Research Proposal Guidelines 2012 |
| Jan 31 | C. elegans genetics | Kerry Kornfeld | |
| Feb 2 | Zebrafish genetics | Kelly Monk | Monk_ZF Genetics 2012_Part1 |
| Feb 6 | Discussion Section- Research proposals II | small groups | Example proposal 1_LongChainFA |
| Feb 7 | Yeast genetics | Susan Dutcher | |
| Feb 9 | Yeast genetics | Susan Dutcher | |
| Feb 13 | Discussion Section | small groups | AmbrosV_1989 |
| Feb 14 | Yeast Genetics | Susan Dutcher | |
| Feb 16 | High throughput genetics | Tim Schedl | |
| Feb 20 |
Discussion Section | small groups | Lum_et_al.Cell 2004 |
| Feb 21 | Drosophila genetics | Jim Skeath | Kornfeld Problem Set Due |
| Feb 23 | Drosophila genetics | Jim Skeath | |
| Feb 27 | Arabidopsis genetics | ||
| Feb 28 | Drosophila genetics | Jim Skeath | |
| Mar 1 | Drosophila genetics | Jim Skeath |
|
| Mar 5 |
Discussion Section – Paper | Small groups | |
| Mar 6 | Mouse genetics | Dave Ornitz | |
| SPRING BREAK – MARCH 10- 18 | |||
| Mar 19 | Abstract and Specific Aims Due for Proposal | ||
| Mar 20 | Quantitative genetics | Justin Fay | |
| Mar 22 | Quantitative genetics | Justin Fay | |
| Mar 26 | Discussion Section-paper TBA | Small groups | |
| Mar 27 | Human genetics | Bowcock/Lovett | |
| Mar 29 | Human genetics | Bowcock/Lovett | |
| Apr 2 |
Discussion Section-paper TBA | Small Groups | |
| Apr 3 | Human genetics | Bowcock/Lovett | |
| Apr 5 | Human genetics | Goodfellow | |
| Apr 9 | Discussion Section |
Small groups | |
| Apr 10 | Human genetics | Bowcock/Lovett | |
| Apr 27 |
Research Proposals due Friday April 27 at 12:00pm (NOON) Email the Proposal to: advancedgenetics@genetics.wustl.edu
|
||
| April 30 | Grants returned for Review – Noon – 823 McDonnell | ||
| May 7,8, and 9 | Study Sections – 1-5pm; 823 McDonnell Sciences (must attend one day) | ||